Abstract | INTRODUCTION:
Intravenous immunoglobulin ( IVIG) is used to treat many inflammatory and autoimmune disorders and although generally well tolerated, cutaneous side effects occur. OBJECTIVE: We reviewed reports of pompholyx and eczematous reactions associated with IVIG. METHODS: RESULTS: We identified 64 cases of eczematous reactions associated with IVIG therapy, including a patient treated on our inpatient consult service. In reported cases, the majority of patients (62.5%) had pompholyx alone or a combination of pompholyx on the hands or feet and two or fewer additional body surfaces involved. The majority of reported cases (75%) experienced the eczematous reaction after their first IVIG treatment. Neurologic conditions were the most common (85.9%) diseases for which IVIG was used. Most patients responded well to topical steroids or did not require treatment. LIMITATIONS: Some reported cases had insufficient descriptions to be included in this review. A literature review may underestimate the frequency of eczematous reactions to IVIG because these reactions are often limited and may not be reported. CONCLUSIONS: With the use of IVIG increasing, it is important for dermatologists to recognize this cutaneous side effect of IVIG.
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Authors | Meg R Gerstenblith, Ashley K Antony, Jacqueline M Junkins-Hopkins, Rachel Abuav |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 66
Issue 2
Pg. 312-6
(Feb 2012)
ISSN: 1097-6787 [Electronic] United States |
PMID | 21601310
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Immunoglobulins, Intravenous
- Steroids
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Topics |
- Adolescent
- Adult
- Aged
- Autoimmune Diseases
(drug therapy)
- Child
- Eczema
(chemically induced, drug therapy)
- Eczema, Dyshidrotic
(chemically induced, drug therapy)
- Female
- Humans
- Immunization, Passive
(adverse effects)
- Immunoglobulins, Intravenous
(adverse effects)
- Male
- Middle Aged
- Steroids
(therapeutic use)
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