Abstract | BACKGROUND: The high prevalence of metabolic syndrome (MetS) has highlighted the need for effective dietary interventions to combat this growing problem. OBJECTIVE: To assess the impact of a Mediterranean-style low-glycemic-load diet (control arm, n = 44) or the same diet plus a medical food containing phytosterols, soy protein, and extracts from hops and acacia (intervention arm, n = 45) on cardiometabolic risk variables in women with MetS. METHODS: In this 12-week, 2-arm randomized trial, baseline, week 8 and 12, fasting blood samples were drawn to measure plasma lipids, apolipoproteins, and homocysteine. Dietary records were also collected and analyzed. RESULTS: CONCLUSION: A Mediterranean-style low-glycemic-load diet effectively reduces the variables of MetS. Addition of the medical food results in a less atherogenic lipoprotein profile and lower plasma homocysteine.
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Authors | Jennifer L Jones, Maria Luz Fernandez, Mark S McIntosh, Wadie Najm, Mariana C Calle, Colleen Kalynych, Clare Vukich, Jacqueline Barona, Daniela Ackermann, Jung Eun Kim, Vivek Kumar, Michelle Lott, Jeff S Volek, Robert H Lerman |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2011 May-Jun
Vol. 5
Issue 3
Pg. 188-196
ISSN: 1933-2874 [Print] United States |
PMID | 21600524
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoproteins
- Blood Glucose
- Cholesterol, LDL
- Homocysteine
- Docosahexaenoic Acids
- C-Reactive Protein
- Eicosapentaenoic Acid
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Topics |
- Adult
- Aged
- Apolipoproteins
(blood)
- Blood Glucose
(analysis)
- C-Reactive Protein
(analysis)
- Cholesterol, LDL
(blood)
- Diet, Mediterranean
- Docosahexaenoic Acids
(therapeutic use)
- Eating
- Eicosapentaenoic Acid
(therapeutic use)
- Female
- Glycemic Index
- Homocysteine
(blood)
- Humans
- Hypercholesterolemia
(diet therapy)
- Metabolic Syndrome
(diet therapy)
- Middle Aged
- Waist Circumference
- Young Adult
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