Abstract | OBJECTIVE: METHODS: RESULTS: The overall response rate in the low dose chemotherapy regimen group was 47.4% (9/19), 6 patients (31.6%) achieved complete response (CR). The overall response rate in the VPA group was 77.2% (17/22), 9 patients (40.9%) achieved CR. The overall response rate of the low dose chemotherapy in combination with VPA group was significantly higher than that in the low dose chemotherapy group (P < 0.05) while no difference was found in CR rate. The adverse effect of the low dose chemotherapy in combination with VPA regimen was tolerated. CONCLUSION: With acceptable adverse effect, the low dose chemotherapy in combination with VPA regimen is effective for the treatment of intermediate and high-risk myelodysplastic syndrome. Long-term outcome needs further investigation.
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Authors | Qing-yi Zhang, Gui-min Ge, Yi-peng Yan, Xiao-lin Han, Yan Huang, Sun Wu, Li-shan He |
Journal | Zhonghua nei ke za zhi
(Zhonghua Nei Ke Za Zhi)
Vol. 50
Issue 3
Pg. 240-2
(Mar 2011)
ISSN: 0578-1426 [Print] China |
PMID | 21600090
(Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Myelodysplastic Syndromes
(drug therapy)
- Retrospective Studies
- Valproic Acid
(administration & dosage, adverse effects, therapeutic use)
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