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Integrin b4 expression in peripheral-nerve tumors.

Abstract
The alpha 6 beta 4 integrin complex is expressed in epithelial, endothelial and nerve cells. We analyzed the immunohistochemical expression of the beta 4 subunit in normal peripheral nerves, in neurofibromas associated with type 1 neurofibromatosis and in sporadic neurofibrosarcomas. In normal peripheral nerves (4 samples), the beta 4 integrin was diffusely expressed at the level of the perinevrium and at the interface between axons and Schwann cells. In neurofibromas (6 cases), beta 4 was undetectable or markedly decreased relative to normal peripheral nerves. Neurofibrosarcomas (3 cases) were immunohistochemically negative for beta 4 expression. These observations suggest that a down-regulation of the alpha 6 beta 4 integrin is associated with the neoplastic progression of peripheral nerve tumors.
AuthorsM Carlesimo, S Giustini, A Richetta, L Ottini, R Marianicostantini, R Falcioni, S Calvieri
JournalOncology reports (Oncol Rep) Vol. 2 Issue 6 Pg. 997-1000 (Nov 1995) ISSN: 1021-335X [Print] Greece
PMID21597841 (Publication Type: Journal Article)

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