Abstract |
We evaluated the safety and efficacy of ethyl loflazepate in children with epilepsy. The study group comprised 21 outpatients (4 by generalized, 17 by localization-related) aged between 9 months and 17 years. Ethyl loflazepate was administered at a dose of 0.015 mg/kg/day twice daily. The final mean dose was 1.35 mg/day. The mean number of prior antiepileptic drugs was 5.7. The entire treatment period was more than 24 months after ethyl loflazepate administration. Six children (28.6%) became seizure-free for the entire study 6 months after administration, 11 (52.4%) had a seizure reduction of more than 50% for over entire 24 months. The mean number of co-medications was 2.4. Adverse events occurred in only 1 patient. Responders, defined as reduction of ≥50% in seizure frequency, included 2/2 of patients with West syndrome and 15/17 (88.2%) with localization-related epilepsy. Ethyl loflazepate represents an important addition to the treatments available for refractory epilepsies in children.
|
Authors | Hideaki Kanemura, Fumikazu Sano, Kanji Sugita, Masao Aihara |
Journal | Journal of child neurology
(J Child Neurol)
Vol. 26
Issue 10
Pg. 1284-9
(Oct 2011)
ISSN: 1708-8283 [Electronic] United States |
PMID | 21596702
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anticonvulsants
- Benzodiazepines
- ethyl loflazepate
|
Topics |
- Adolescent
- Anticonvulsants
(therapeutic use)
- Benzodiazepines
(therapeutic use)
- Child
- Child, Preschool
- Epilepsy
(drug therapy)
- Female
- Follow-Up Studies
- Humans
- Infant
- Japan
- Male
- Outpatients
- Time Factors
|