Comparison of posterior capsule opacification with hydrophobic acrylic and hydrophilic acrylic intraocular lenses.

Abstract

PURPOSE:

To compare posterior capsule opacification (PCO) 3 years postoperatively in contralateral eyes with a single-piece hydrophobic acrylic and 1 of 2 single-piece hydrophilic acrylic intraocular lenses (IOLs) with different configurations.

SETTING:

Iladevi Cataract and IOL Research Institute, Ahmedabad, India.

DESIGN:

Prospective randomized clinical trial.

METHODS:

A hydrophobic Acrysof (hydrophobic group) or a hydrophilic C-flex (hydrophilic group C) or Akreos Adapt IOL (hydrophilic group A) was randomized for implantation in the fellow eye or vice versa of each patient. The Evaluation of Posterior Capsule Opacification (EPCO) area, EPCO score, and neodymium:YAG (Nd:YAG) capsulotomy rates were compared using digital photographs.

RESULTS:

The study enrolled 68 patients. Although there was no significant difference at 1 month, the median EPCO score was statistically significantly lower in the hydrophobic group than in hydrophilic group C (P = .00) and hydrophilic group A (P = .000) at 3 years. There were no significant differences in the median EPCO area at 1 month; however, the area was statistically significantly less in the hydrophobic group than in hydrophilic group C and hydrophilic group A at 3 years (both P = .000). Four (12.9%) of 31 eyes in hydrophilic group C and 5 (16%) of 31 eyes in hydrophilic group A required an Nd:YAG capsulotomy; no eye in the hydrophobic group required a capsulotomy (P = .04 and P = .02, respectively).

CONCLUSION:

Posterior capsule opacification was significantly less with the Acrysof hydrophobic acrylic IOL at 3 years.

FINANCIAL DISCLOSURE:

No author has a financial or proprietary interest in any material or method mentioned.

• Authors: Abhay R Vasavada, Shetal M Raj, Alpesh Shah, Gauri Shah, Viraj Vasavada, Vaishali Vasavada
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 37 Issue 6 Pg. 1050-9 (Jun 2011) ISSN: 1873-4502 [Electronic] United States
• PMID: 21596247 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Acrylic Resins

Topics

• Acrylic Resins
• Aged
• Capsule Opacification (etiology, surgery)
• Female
• Humans
• Hydrophobic and Hydrophilic Interactions
• Laser Therapy
• Lasers, Solid-State
• Lens Implantation, Intraocular
• Lenses, Intraocular (adverse effects)
• Male
• Phacoemulsification
• Posterior Capsule of the Lens (pathology, surgery)
• Postoperative Complications
• Prospective Studies
• Refraction, Ocular (physiology)
• Visual Acuity (physiology)