[Syndrome CINCA/NOMID].

Abstract

CINCA/NOMID syndrome was first reported in 1981, identified as a new disease in 1987 and the main cause discovered in 2001, when mutations in the CIAS1 gene modifying the structure of the protein cryopirin were found in those patients (although other factors seem to play a role). Together with the major symptoms that characterized the syndrome, neurological, cutaneous and articular manifestations, others have been added which seem to be quite constant among CINCA/NOMID diagnosed patients: pre and perinatal symptoms, morfological changes, outbreaks of fever and biological abnormalities which reveal a persistent inflammatory background. The radiological studies have been able to identify the physis as the origin of the osteoarticular malformations seen in this syndrome. Diferential diagnosis includes diseases with similar onset at the neonatal period or infancy: systemic onset juvenile idiopathic athritis, periodic fever associated with mevalonate kinase deficiency, deficiency of IL-1 receptor antagonist (DIRA) and Muckle-Wells syndrome.

• Authors: Consuelo Modesto
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 136 Suppl 1 Pg. 10-5 (Jan 2011) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Síndrome CINCA/NOMID.
• PMID: 21596181 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2011 Elsevier España S.L. All rights reserved.

Chemical References

• Carrier Proteins
• NLR Family, Pyrin Domain-Containing 3 Protein
• NLRP3 protein, human

Topics

• Age of Onset
• Arthralgia (diagnostic imaging, etiology)
• Carrier Proteins (chemistry, genetics, physiology)
• Cryopyrin-Associated Periodic Syndromes (diagnosis, epidemiology, genetics, physiopathology)
• Diagnosis, Differential
• Disease Susceptibility
• Female
• Fetal Diseases (etiology)
• Growth Disorders (etiology)
• Hereditary Autoinflammatory Diseases (classification, diagnosis)
• Humans
• NLR Family, Pyrin Domain-Containing 3 Protein
• Nervous System Diseases (etiology)
• Obstetric Labor, Premature (etiology)
• Phenotype
• Pregnancy
• Radiography
• Urticaria (etiology)