Parathyroidectomy markedly reduces oxidative stress in a patient with primary hyperparathyroidism.

Parathyroidectomy for hyperparathyroidism has been associated with a survival benefit, but the mechanisms remain unclear. We are reporting on an 88-year-old female patient who had high serum calcium and intact parathyroid hormone levels associated with an enlarged parathyroid gland. A parathyroidectomy was performed due to a diagnosis of primary hyperparathyroidism. After the surgery, there was a marked decrease in the oxidative stress markers, such as the ratios of oxidized to unoxidized albumin and advanced oxidation protein products. These results suggest that parathyroidectomy reduces oxidative stress in patients with primary hyperparathyroidism, which may in part explain the reduced risk for cardiovascular and all-cause mortality after parathyroidectomy.
AuthorsMotoko Tanaka, Koki Tokunaga, Toru Maruyama, Masaki Otagiri, Yoshihiro Tominaga, Kazuko Itoh, Kazutaka Matsushita, Hirotaka Komaba, Masafumi Fukagawa
JournalTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 15 Suppl 1 Pg. 38-41 (Jun 2011) ISSN: 1744-9987 [Electronic] Australia
PMID21595851 (Publication Type: Case Reports, Journal Article)
Copyright© 2011 The Authors. Therapeutic Apheresis and Dialysis © 2011 International Society for Apheresis.
Chemical References
  • Parathyroid Hormone
  • Serum Albumin
  • Calcium
  • Aged, 80 and over
  • Calcium (blood)
  • Female
  • Humans
  • Hyperparathyroidism, Primary (surgery)
  • Oxidation-Reduction
  • Oxidative Stress
  • Parathyroid Glands (pathology)
  • Parathyroid Hormone (blood)
  • Parathyroidectomy (methods)
  • Serum Albumin (metabolism)

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