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An outbreak of granulomatous peritonitis caused by injectable selenium in a flock of Merino sheep.

Abstract
During meat inspection, unusual pigmented lesions were found in the abdomens of 411 sheep from a flock raised in the Northern Tablelands of New South Wales. In each affected sheep there were multiple discrete, soft, yellow homogeneous plaques beneath the parietal peritoneum and extending into marginating facial planes of the diaphragm and body wall. Microscopically, the lesions consisted of focal granulomatous peritonitis with intracellular acicular refractile golden-brown crystals. Energy dispersive X-ray spectroscopy revealed intralesional barium and selenium, two components of an injectable selenium compound administered to the sheep 6-8 months prior, which contains the yellow pigment, iron oxide. The mechanism of subperitoneal deposition of the compound could not be confirmed, but is presumed to have involved intraperitoneal injection of barium selenate. Meat inspectors and diagnosticians should consider barium selenate injection-site granulomas as a possible explanation for yellow pigmented lesions, especially in livestock from selenium-deficient areas. Animal care providers should be aware that incorrect administration of barium selenate can result in losses from condemnation or downgrading of meat product.
AuthorsM M Dennis, J Henriquez, G Keipert, J Biazik, F Braet
JournalAustralian veterinary journal (Aust Vet J) Vol. 89 Issue 6 Pg. 209-12 (Jun 2011) ISSN: 1751-0813 [Electronic] England
PMID21595640 (Publication Type: Journal Article)
Copyright© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.
Chemical References
  • Barium Compounds
  • Delayed-Action Preparations
  • Selenium Compounds
  • Selenium
  • Selenic Acid
  • barium selenate
Topics
  • Animals
  • Barium Compounds (administration & dosage, adverse effects)
  • Delayed-Action Preparations (administration & dosage, adverse effects)
  • Food Inspection
  • Injections, Intraperitoneal (veterinary)
  • Meat (standards)
  • Peritonitis (chemically induced, pathology, veterinary)
  • Pigmentation
  • Selenic Acid
  • Selenium (deficiency)
  • Selenium Compounds (administration & dosage, adverse effects)
  • Sheep
  • Sheep Diseases (chemically induced, pathology)

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