Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias.

Abstract

There is increasing evidence that in Lewy body-associated dementias (encompassing Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB)), the adaptive immune system is altered and the degenerative process includes glial cells in addition to neuronal structures. We therefore aimed to determine levels of autoantibodies against amyloid and glial-derived structures in these dementia types. Using a newly developed Enzyme-linked immunosorbent assay (ELISA), we measured levels of IgG autoantibodies against neuronal and glial structures in serum and cerebrospinal fluid of a total of 91 subjects (13 PDD, 14 DLB, 11 Alzheimer's disease (AD), 11 frontotemporal dementia (FTD), 11 vascular dementia patients (VaD), and 31 healthy controls). Autoantibody levels against α-synuclein, amyloid-β₄₂ (Aβ₄₂), myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), and S100B were determined. In all groups, autoantibody levels were about three magnitudes higher in serum than in CSF. Serum autoantibody levels against α-synuclein, Aβ₄₂, MOG, MBP, and S100B were higher in PDD/DLB compared to tau-associated dementias (AD, FTD), VaD, and controls, respectively, with most of them reaching highly significant p-values. In cerebrospinal fluid (CSF), levels of antibodies against oligodendrocyte-derived antigens (MOG, MBP) were significantly increased in PDD/DLB. Increased levels of autoantibodies against both neuronal- and glial-derived antigens in serum and CSF of Lewy body-associated dementias indicate an altered activity of the adaptive immune system in these dementia types. The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated.

• Authors: Walter Maetzler, Daniela Berg, Matthis Synofzik, Kathrin Brockmann, Jana Godau, Arthur Melms, Thomas Gasser, Stephanie Hörnig, Markus Langkamp
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 26 Issue 1 Pg. 171-9 ( 2011) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 21593566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Autoantibodies
• MOG protein, human
• Myelin Basic Protein
• Myelin Proteins
• Myelin-Oligodendrocyte Glycoprotein
• Nerve Growth Factors
• Peptide Fragments
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins
• S100B protein, human
• alpha-Synuclein
• amyloid beta-protein (1-42)

Topics

• Aged
• Alzheimer Disease (blood, cerebrospinal fluid)
• Amyloid beta-Peptides (immunology)
• Autoantibodies (blood, cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay
• Female
• Frontotemporal Dementia (blood, cerebrospinal fluid)
• Humans
• Lewy Body Disease (blood, cerebrospinal fluid)
• Male
• Myelin Basic Protein (immunology)
• Myelin Proteins (immunology)
• Myelin-Oligodendrocyte Glycoprotein
• Nerve Growth Factors (immunology)
• Peptide Fragments (immunology)
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins (immunology)
• alpha-Synuclein (immunology)