Abstract | OBJECTIVE: To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very low birth weight infants enrolled in the Caffeine for Apnea of Prematurity (CAP) Trial. STUDY DESIGN: The CAP Trial enrolled 2006 infants with birthweights between 500 and 1250 g who were eligible for caffeine therapy. All levels of delivery room resuscitation were recorded in study participants. We divided infants in 4 groups of increasing intensity of resuscitation: minimal, n = 343; bag-mask ventilation, n = 372; endotracheal intubation, n = 1205; and cardiopulmonary resuscitation (chest compressions/ epinephrine), n = 86. We used multivariable logistic regression models to compare outcomes across the 4 groups. RESULTS: CONCLUSIONS: In CAP Trial participants, the risk of death or neurodevelopmental disability at 18 months did not increase substantially with increasing intensity of delivery room resuscitation.
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Authors | Sara B DeMauro, Robin S Roberts, Peter Davis, Ruben Alvaro, Aida Bairam, Barbara Schmidt, Caffeine for Apnea of Prematurity Trial Investigators |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 159
Issue 4
Pg. 546-50.e1
(Oct 2011)
ISSN: 1097-6833 [Electronic] United States |
PMID | 21592510
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Topics |
- Brain Injuries
(epidemiology)
- Bronchopulmonary Dysplasia
(epidemiology)
- Cardiopulmonary Resuscitation
(adverse effects)
- Cerebral Palsy
(epidemiology)
- Delivery Rooms
- Developmental Disabilities
(epidemiology)
- Enterocolitis, Necrotizing
(epidemiology)
- Female
- Hearing Loss
(epidemiology)
- Humans
- Infant Mortality
- Infant, Newborn
- Infant, Premature
- Infant, Very Low Birth Weight
- Intubation, Intratracheal
(adverse effects)
- Male
- Masks
- Multivariate Analysis
- Respiration, Artificial
(adverse effects)
- Retinopathy of Prematurity
(epidemiology)
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