Efficacy of peripartum antiviral treatment for hepatic failure due to hepatitis B virus.

Abstract

OBJECTIVE:

To investigate the efficacy of oral nucleosides in preventing hepatic failure during pregnancy (HFP) caused by hepatitis B virus (HBV) infection.

METHODS:

Besides receiving standard treatment, 70 women with HFP caused by HBV infection joined a study group (n = 40) or a control group (n = 30) according to their preference. In the study group, 14 women were given lamivudine in the third trimester and an antiviral treatment was continued postpartum. The 26 remaining patients were treated postpartum only, with lamivudine (n = 16) or entecavir (n = 10).

RESULTS:

In the study group, the values for serum HBV DNA and hepatitis B envelope antigen were markedly lower at 1 and 2 months than they were at baseline (P < 0.001 and P < 0.001, respectively). Moreover, the HBV DNA values at 1 and 2 months were significantly lower in the study than in the control group (P < 0.05). Overall mortality and incidence of intrauterine infection were also significantly lower in the study group (P < 0.05). No newborns had any apparent abnormalities in either group.

CONCLUSION:

Treatment with nucleosides suppressed the replication of HBV DNA and led to biochemical improvement. It also reduced maternal mortality and safely decreased mother-to-child HBV transmission.

• Authors: Minmin Yu, Ying Ji, Hongxiu Jiang, Lili Ju, Kaihua Wu, Naiying Kan
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 114 Issue 1 Pg. 33-6 (Jul 2011) ISSN: 1879-3479 [Electronic] United States
• PMID: 21592475 (Publication Type: Controlled Clinical Trial, Journal Article)
• Copyright: Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• DNA, Viral
• Hepatitis B e Antigens
• Lamivudine
• entecavir
• Guanine

Topics

• Adult
• Antiviral Agents (therapeutic use)
• DNA, Viral (blood)
• Female
• Guanine (analogs & derivatives, therapeutic use)
• Hepatitis B (complications, drug therapy, transmission)
• Hepatitis B e Antigens (blood)
• Humans
• Infant, Newborn
• Lamivudine (therapeutic use)
• Liver Failure (prevention & control, virology)
• Maternal Mortality
• Postpartum Period
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Pregnancy Trimester, Third
• Time Factors
• Treatment Outcome
• Uterine Diseases (epidemiology, virology)
• Virus Replication (drug effects)
• Young Adult