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Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survival.

AbstractBACKGROUND:
The family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) is responsible for the altered glycosylation in cancer. The purpose of our study was to investigate the clinical significance of two isoforms, GalNAc-T6 and -T3, and their correlation with the prognosis of pancreatic cancer.
METHODS:
Immunohistochemistry was used to analyse GalNAc-T6 and -T3 expressions in 70 clinicopathologically characterised pancreatic cancer cases.
RESULTS:
Positive expressions of GalNAc-T6 and -T3 were immunohistochemically identified in 51% (36 of 70) and in 77% (54 of 70) of patients, respectively. A close relationship was noted between GalNAc-T6 positive expression and pathological well/moderate differentiated type (P=0.001), small tumour size (P=0.044), absence of vascular invasion (P=0.009), and low stage of the American Joint Committee on Cancer systems (P=0.043). The expression of GalNAc-T3 significantly correlated with good differentiation (P=0.001), but not with other clinicopathologic features. Furthermore, univariate and multivariate analyses revealed that GalNAc-T6 expression was an independent prognosis indicator for the disease, whereas GalNAc-T3 expression had no impact on clinical outcome, even though 33 of 36 GalNAc-T6-positive cases also had a positive expression of GalNAc-T3 (P=0.001, r=0.356).
CONCLUSION:
Both GalNAc-T6 and -T3 expressions correlated significantly with tumour differentiation, whereas only GalNAc-T6 expression predicted prognosis in pancreatic cancer.
AuthorsZ Li, S Yamada, S Inenaga, T Imamura, Y Wu, K-Y Wang, S Shimajiri, R Nakano, H Izumi, K Kohno, Y Sasaguri
JournalBritish journal of cancer (Br J Cancer) Vol. 104 Issue 12 Pg. 1882-9 (Jun 07 2011) ISSN: 1532-1827 [Electronic] England
PMID21587259 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • N-Acetylgalactosaminyltransferases
  • UDP-N-acetylgalactosamine polypeptide N-acetylgalactosaminyltransferase 6
  • polypeptide N-acetylgalactosaminyltransferase
Topics
  • Adult
  • Aged
  • Cell Line, Tumor
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • N-Acetylgalactosaminyltransferases (analysis)
  • Pancreatic Neoplasms (enzymology, mortality, pathology)
  • Prognosis

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