Abstract | BACKGROUND: METHODS: Immunohistochemistry was used to analyse GalNAc-T6 and -T3 expressions in 70 clinicopathologically characterised pancreatic cancer cases. RESULTS: Positive expressions of GalNAc-T6 and -T3 were immunohistochemically identified in 51% (36 of 70) and in 77% (54 of 70) of patients, respectively. A close relationship was noted between GalNAc-T6 positive expression and pathological well/moderate differentiated type (P=0.001), small tumour size (P=0.044), absence of vascular invasion (P=0.009), and low stage of the American Joint Committee on Cancer systems (P=0.043). The expression of GalNAc-T3 significantly correlated with good differentiation (P=0.001), but not with other clinicopathologic features. Furthermore, univariate and multivariate analyses revealed that GalNAc-T6 expression was an independent prognosis indicator for the disease, whereas GalNAc-T3 expression had no impact on clinical outcome, even though 33 of 36 GalNAc-T6-positive cases also had a positive expression of GalNAc-T3 (P=0.001, r=0.356). CONCLUSION:
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Authors | Z Li, S Yamada, S Inenaga, T Imamura, Y Wu, K-Y Wang, S Shimajiri, R Nakano, H Izumi, K Kohno, Y Sasaguri |
Journal | British journal of cancer
(Br J Cancer)
Vol. 104
Issue 12
Pg. 1882-9
(Jun 07 2011)
ISSN: 1532-1827 [Electronic] England |
PMID | 21587259
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- N-Acetylgalactosaminyltransferases
- UDP-N-acetylgalactosamine polypeptide N-acetylgalactosaminyltransferase 6
- polypeptide N-acetylgalactosaminyltransferase
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Topics |
- Adult
- Aged
- Cell Line, Tumor
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- N-Acetylgalactosaminyltransferases
(analysis)
- Pancreatic Neoplasms
(enzymology, mortality, pathology)
- Prognosis
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