Abstract | OBJECTIVES: This experimental work was designed to investigate the efficacy of prebiotic by itself and in combination with Hyppocastani extractum siccum, and Lini oleum virginale on selected parameters in rats with dimethylhydrazine induced colon cancer. METHODS: Rats were randomly divided into 5 experimental groups of 12 rats each. Rats were fed with high fat (HF) diet containing 10 % of fat, supplemented by prebiotic at a dose of 2 % of HF diet itself and in combination with Hyppocastani extractum siccum at a dose of 1 % of diet and Lini oleum virginale at a dose of 2 % of diet. Two weeks after the start of the diet dimethylhydrazine injections in dose 20 mg/kg b.w. were applied ( DMH, Merck, DE), two times at week interval. The activity of beta-glucuronidase, concentration of lipid parameters, bile acids and short chain fatty acids were determined. RESULTS: CONCLUSION:
Prebiotics have protective effect and may be the useful candidate agents for colon cancer prevention and treatment. The application of selected bioactive food components supported the effect of prebiotics (Tab. 2, Fig. 1, Ref. 16). Full Text in free PDF www.bmj.sk.
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Authors | E Hijova, A Chmelarova, A Bomba |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 112
Issue 4
Pg. 161-4
( 2011)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 21585119
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Plant Extracts
- Prebiotics
- Linseed Oil
- Inulin
- Glucuronidase
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Topics |
- Aesculus
- Animals
- Colonic Neoplasms
(metabolism, prevention & control)
- Dietary Supplements
- Glucuronidase
(metabolism)
- Inulin
- Linseed Oil
(administration & dosage)
- Plant Extracts
(administration & dosage)
- Prebiotics
- Rats
- Rats, Wistar
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