Age and gender specific cut-off values to improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrence.

Abstract

The Prolong study shows that continuing vitamin K antagonists (VKA) in patients with abnormal D-dimer (evaluated by a qualitative assay, Clearview Simplify D-dimer) results in a significant reduction of venous thromboembolism (VTE) recurrence. The present study retrospectively analyzes a subgroup of patients enrolled in the Prolong study with a view to calculate cut-off values for six quantitative D-dimer methods to predict the risk of VTE recurrence. We measured D-dimer levels by VIDAS D-dimer Exclusion (bioMerieux), STA Liatest D-dimer (DiagnosticaStago), HemosIL D-dimer and HemosIL D-dimer HS (Instrumentation Laboratory), Innovance D-dimer (Siemens) and AutoDimer (Trinity Biotech) in frozen plasma aliquots sampled 30 ± 10 days after VKA cessation in 390 patients enrolled in the Prolong study. During follow-up (562.7 years), 28 patients had recurrent VTE (7.2%, 5.0% person-years). Since D-dimer levels are positively correlated with age and significantly lower in men, we calculated method-specific cut-off values according to age and gender. The HRs for VTE recurrence calculated using method-specific cut-off values based on age and gender are higher than those using cut-off values indicated by the manufacturers for VTE exclusion in symptomatic outpatients. These data suggest that method-specific cut-off values calculated according to patient age and gender can be more accurate in identifying patients at a higher risk for VTE recurrence. These method-specific cut-off values are being evaluated in the ongoing prospective management multicenter DULCIS study.

• Authors: Cristina Legnani, Michela Cini, Benilde Cosmi, Paolo Carraro, Armando Tripodi, Nicoletta Erba, Gualtiero Palareti
• Journal: Internal and emergency medicine (Intern Emerg Med) Vol. 8 Issue 3 Pg. 229-36 (Apr 2013) ISSN: 1970-9366 [Electronic] Italy
• PMID: 21584847 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Fibrinogen Degradation Products
• Fibrinolytic Agents
• fibrin fragment D
• Vitamin K

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Fibrinolytic Agents
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Recurrence
• Retrospective Studies
• Risk Factors
• Sex Factors
• Venous Thromboembolism (blood, drug therapy, etiology)
• Vitamin K (antagonists & inhibitors)
• Young Adult