Abstract | BACKGROUND: METHODS: RESULTS: Seventeen patients had measurable lymph node metastases by the RECIST criteria. CT examination showed response to the treatment in ten (59%, 0 complete response, 10 partial response). Of the 25 patients, 14 (56%) showed negative results on peritoneal cytology with no macroscopic peritoneal metastasis, whereas the remaining 11 were cancer cell-positive on peritoneal cytology or macroscopic peritoneal metastasis even after NIPS. The median survival time for all 25 patients was 16.7 months. Prognosis was better in patients who showed negative cytology and disappearance of peritoneal cancer metastases after NIPS than in those with positive cytology or existing peritoneal deposits (P < 0.0001). The predominant toxicity was myelosuppression and grade 3-4 leukopenia and neutropenia occurred in 20 (80%) patients, which were manageable. No treatment-related mortality was observed during and after NIPS and surgery. CONCLUSIONS: The results of this prospective phase II study indicated that the newly designed NIPS was highly effective and well tolerated in patients with advanced gastric cancer and peritoneal dissemination.
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Authors | Yoshiyuki Fujiwara, Shuji Takiguchi, Kiyokazu Nakajima, Hiroshi Miyata, Makoto Yamasaki, Yukinori Kurokawa, Kaoru Okada, Masaki Mori, Yuichiro Doki |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 13
Pg. 3726-31
(Dec 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21584835
(Publication Type: Journal Article)
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Chemical References |
- Taxoids
- Docetaxel
- Cisplatin
- Fluorouracil
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Adjuvant
- Cisplatin
(administration & dosage)
- Docetaxel
- Feasibility Studies
- Female
- Fluorouracil
(administration & dosage)
- Follow-Up Studies
- Gastrectomy
- Humans
- Lymph Node Excision
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Recurrence, Local
(drug therapy, mortality, pathology)
- Neoplasm Staging
- Peritoneal Neoplasms
(drug therapy, mortality, secondary)
- Postoperative Complications
- Prognosis
- Prospective Studies
- Stomach Neoplasms
(drug therapy, mortality, pathology)
- Survival Rate
- Taxoids
(administration & dosage)
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