Abstract |
There is now considerable evidence that the N-methyl-D-aspartic acid receptor is important in the genesis of seizures. One of the selective antagonist of the NMDA receptor is 2-amino-7-phosphonoheptanoic acid (APH). In this study we evaluated the effects of intracerebroventricular (i.c.v.) administration of APH on seizure susceptibility in both prepubescent and mature rats using the rapid kindling and flurothyl ether seizure models. Both the immature and mature animals receiving APH kindled at a significantly slower rate than control animals receiving phosphate-buffered saline. APH also demonstrated a significant anticonvulsant effect against flurothyl-induced seizures in both the immature and mature animals. This study supports prior work that selective NMDA receptor antagonists such as APH may have promise as potential antiepileptic agents.
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Authors | G L Holmes, J L Thompson, G F Carl, B S Gallagher, J Hoy, M McLaughlin |
Journal | Epilepsy research
(Epilepsy Res)
Vol. 5
Issue 2
Pg. 125-30
(Mar 1990)
ISSN: 0920-1211 [Print] Netherlands |
PMID | 2158439
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amino Acids
- Receptors, N-Methyl-D-Aspartate
- Receptors, Neurotransmitter
- 2-Amino-5-phosphonovalerate
- 2-amino-7-phosphonoheptanoic acid
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Topics |
- 2-Amino-5-phosphonovalerate
(analogs & derivatives)
- Amino Acids
(pharmacology)
- Animals
- Injections, Intraventricular
- Kindling, Neurologic
(drug effects)
- Male
- Rats
- Rats, Inbred Strains
- Receptors, N-Methyl-D-Aspartate
- Receptors, Neurotransmitter
(antagonists & inhibitors, physiology)
- Seizures
(chemically induced, metabolism, physiopathology)
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