Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome.

Abstract

A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.

• Authors: Hikaru Doi, Kimiyoshi Arimura, Yasumasa Ohyagi, Jun-Ichi Kira
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 50 Issue 10 Pg. 1113-5 ( 2011) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21576838 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Potassium Channels, Voltage-Gated

Topics

• Adult
• Autoantibodies (blood)
• Autonomic Nervous System (immunology, physiopathology)
• Female
• Frostbite (diagnosis)
• Humans
• Isaacs Syndrome (diagnosis, immunology, pathology, physiopathology)
• Potassium Channels, Voltage-Gated (antagonists & inhibitors, immunology)