Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer.

Abstract

The treatment of base of tongue (BOT) cancer is highly controversial with differing options according to individual institutions, or the primary surgical or radiation therapy bias. We aimed to determine patient outcomes and discuss technical aspects following treatment with concurrent radiation therapy and targeted cisplatin chemotherapy (RADPLAT). We utilized RADPLAT for the definitive treatment of patients with BOT cancers. The 5-year local control and overall survival rate was 92.3% and 90.9% for all patients, respectively, and all surviving patients achieved normal swallowing without a feeding-tube and normal speech without tracheostoma after treatment. Our study found that RADPLAT gave excellent survival rates and organ functions for patients with BOT cancers. We consider that BOT cancer is a good indication for RADPLAT and that the angiographic technique and patient selection are keys to success.

• Authors: Satoshi Kano, Akihiro Homma, Nobuhiko Oridate, Fumiyuki Suzuki, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Jun Furusawa, Tomohiro Sakashita, Daisuke Yoshida, Rikiya Onimaru, Hiroki Shirato, Satoshi Fukuda
• Journal: Oral oncology (Oral Oncol) Vol. 47 Issue 7 Pg. 665-70 (Jul 2011) ISSN: 1879-0593 [Electronic] England
• PMID: 21576034 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Aged
• Antineoplastic Agents (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, pathology, radiotherapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy (methods)
• Female
• Humans
• Infusions, Intra-Arterial (methods)
• Lymphatic Metastasis
• Male
• Middle Aged
• Survival Rate
• Tongue Neoplasms (drug therapy, pathology, radiotherapy)
• Treatment Outcome