Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-α agonist treatment.

Abstract

The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected interventions. We measured serum FGF-19 levels and other biochemical and hormonal parameters in 29 OB and 19 T2DM females and 30 sex- and age-matched control subjects. The interventions were acute hyperinsulinemia during isoglycemic-hyperinsulinemic clamp (n=11 for T2DM and 10 for C), very-low calorie diet (VLCD, n=12 for OB) and 3 months treatment with PPAR-alpha agonist fenofibrate (n=11 for T2DM). Baseline serum FGF-19 levels were significantly lower in OB relative to C group (132.1+/-12.7 vs. 202.2+/-16.7 pg/ml, p<0.05), while no significant difference was observed between T2DM and OB or control group. Acute hyperinsulinemia tended to decrease FGF-19 levels in both healthy and T2DM subjects. Three weeks of VLCD in OB group had no significant effect on FGF-19, whereas three months of fenofibrate treatment markedly reduced FGF-19 levels in T2DM patients (194.58+/-26.2 vs. 107.47+/-25.0 pg/ml, p<0.05). We conclude that FGF-19 levels in our study were at least partially dependent upon nutritional status, but were not related to parameters of glucose metabolism or insulin sensitivity.

• Authors: M Mráz, Z Lacinová, P Kaválková, D Haluzíková, P Trachta, J Drápalová, V Hanušová, M Haluzík
• Journal: Physiological research (Physiol Res) Vol. 60 Issue 4 Pg. 627-36 ( 2011) ISSN: 1802-9973 [Electronic] Czech Republic
• PMID: 21574752 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Blood Glucose
• FGF19 protein, human
• PPAR alpha
• Fibroblast Growth Factors
• Fenofibrate

Topics

• Acute Disease
• Adult
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Caloric Restriction (methods)
• Diabetes Mellitus, Type 2 (blood, therapy)
• Female
• Fenofibrate (pharmacology, therapeutic use)
• Fibroblast Growth Factors (blood)
• Humans
• Hyperinsulinism (blood, therapy)
• Insulin Resistance
• Middle Aged
• Obesity (blood)
• PPAR alpha (agonists, physiology)
• Treatment Outcome