[Intra-arterial infusion of cisplatin and caffeine for a recurrent malignant fibrous histiocytoma].

Abstract

We treated a 43-year-old man with recurrent malignant fibrous histiocytoma in right distal femur with intra-arterial infusion of cisplatin and caffeine 5 years after wide excision and chemotherapy. At the time of the first recurrence in the lateral aspect of thigh, intra-arterial infusion of CDDP (120 mg/m2) was ineffective. We treated him with radiation (7000 rad), and there was no evidence of tumor by radiological evaluation. The second local recurrence was treated with intra-arterial infusion of CDDP (120 mg/m2/1 hour) and caffeine (1.2 g/m2/24 hours x 3 days), and the tumor disappeared, radiologically and histologically. Caffeine did not increase the nephrotoxicity of CDDP, and no insomnia nor palpitation was seen. Intra-arterial infusion of CDDP and caffeine could be useful to increase the effect of CDDP for regional chemotherapy.

• Authors: H Tsuchiya, K Tomita, H Yasutake, H Morishita, S Morikawa, M Ono, T Tsuchida, Y Takagi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 4 Pt 1 Pg. 681-4 (Apr 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 2157370 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Caffeine
• Cisplatin

Topics

• Adult
• Caffeine (administration & dosage)
• Cisplatin (administration & dosage, therapeutic use)
• Femoral Neoplasms (drug therapy, pathology)
• Histiocytoma, Benign Fibrous (drug therapy, pathology)
• Humans
• Infusions, Intra-Arterial
• Male
• Neoplasm Recurrence, Local (drug therapy)