Polyadenylic acid polymerase activity in chronic myelogenous leukemia.

Abstract

Poly(A) polymerase activity was markedly elevated in CML in the blastic phase, moderately high in the accelerated phase and low in the chronic phase. The activity was significantly higher in the myeloid crisis than in the lymphoid crisis and elevated with increasing ratio of blasts in leukemia cases. In TPA or retinoic acid-treated leukemia cells poly(A) polymerase activity was decreased. These results suggest that poly(A) polymerase activity changes, depending on the maturation of leukemic cells and the assay of this enzyme activity may be useful for the early detection of the exacerbation of CML cases.

• Authors: R Sasaki, J Minowada, F J Bollum, Y Miura
• Journal: Leukemia research (Leuk Res) Vol. 14 Issue 3 Pg. 273-8 ( 1990) ISSN: 0145-2126 [Print] England
• PMID: 2157115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tretinoin
• Nucleotidyltransferases
• Polynucleotide Adenylyltransferase
• Tetradecanoylphorbol Acetate

Topics

• Blast Crisis (enzymology)
• Bone Marrow (enzymology)
• Cell Line
• Humans
• Kinetics
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (enzymology, pathology)
• Nucleotidyltransferases (metabolism)
• Polynucleotide Adenylyltransferase (blood, metabolism)
• Tetradecanoylphorbol Acetate (pharmacology)
• Tretinoin (pharmacology)
• Tumor Cells, Cultured (enzymology)