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A view on sphingolipids and disease.

Abstract
Sphingolipid and glycosphingolipid levels and expression of sphingolipid metabolizing enzymes are altered in a variety of diseases or in response to drug treatment. Inherited defects of enzymes and other proteins required for the lysosomal degradation of these lipids lead to human sphingolipidoses. Also genetic defects that affect sphingolipid biosynthesis are known. Although the molecular details are often far from clear, (glyco)sphingolipids have been implicated to play a role in atherosclerosis, insulin resistance, cancer, and infections by pathogens. More general aspects of selected diseases are discussed.
AuthorsThomas Kolter
JournalChemistry and physics of lipids (Chem Phys Lipids) Vol. 164 Issue 6 Pg. 590-606 (Sep 2011) ISSN: 1873-2941 [Electronic] Ireland
PMID21570958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Glycosphingolipids
  • Sphingolipids
Topics
  • Animals
  • Carbohydrate Sequence
  • Disease (genetics)
  • Glycosphingolipids (biosynthesis, chemistry, metabolism)
  • Humans
  • Lysosomes (metabolism)
  • Molecular Sequence Data
  • Sphingolipidoses (chemically induced, enzymology, metabolism, pathology)
  • Sphingolipids (biosynthesis, chemistry, metabolism)

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