Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management.

Abstract

Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400) is a preservative found in both personal care products and industrial sources. Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. Issues related to patch-test preparations are also discussed.

• Authors: Angela E Aakhus, Erin M Warshaw
• Journal: Dermatitis : contact, atopic, occupational, drug (Dermatitis) Vol. 22 Issue 3 Pg. 127-40 (May 2011) ISSN: 2162-5220 [Electronic] United States
• PMID: 21569742 (Publication Type: Journal Article, Review)

Chemical References

• Ethylene Glycols
• Nitriles
• Preservatives, Pharmaceutical
• phenoxyethanol
• 1,2-dibromo-2,4-dicyanobutane

Topics

• Animals
• Consumer Product Safety (legislation & jurisprudence)
• Dermatitis, Allergic Contact (diagnosis, epidemiology, therapy)
• Ethylene Glycols (adverse effects, chemistry)
• Europe (epidemiology)
• Guinea Pigs
• Humans
• Nitriles (adverse effects, chemistry)
• Patch Tests
• Preservatives, Pharmaceutical (adverse effects, chemistry)
• United States (epidemiology)