Abstract | BACKGROUND: METHODS: We prospectively included 129 patients with ischemic stroke (58.1% male; mean age, 72.4 ± 9.6 years) not treated with tPA within 12 hours (h) of symptoms onset (mean time, 4.7 ± 2.1 h). Poor functional outcome at 3 months was considered as a modified Rankin scale score >2. Serum levels of neuroserpin, Interleukin 6 (IL-6), Intercellular adhesion molecule-1 (ICAM-1), active Matrix metalloproteinase 9 (MMP-9), and cellular fibronectin (cFn) (determined by ELISA) and glutamate (determined by HPLC) were measured on admission, 24 and 72 h. The main variable was considered the decrease of neuroserpin levels within the first 24 h. ROC analysis was used to select the best predictive value for neuroserpin to predict poor functional outcome due to a lack of linearity. RESULTS: The decrease of neuroserpin levels within the first 24 h was negatively correlated with serum levels at 24 hours of glutamate (r = -0.642), IL-6 (r = -0.678), ICAM-1 (r = -0.345), MMP-9 (r = -0.554) and cFn (r = -0.703) (all P < 0.0001). In the multivariate analysis, serum levels of glutamate (OR, 1.04; CI95%, 1.01-1.06, p = 0.001); IL-6 (OR, 1.4; CI95%, 1.1-1.7, p = 0.001); and cFn (OR, 1.3; CI95%, 1.1-1.6, p = 0.002) were independently associated with a decrease of neuroserpin levels <70 ng/mL at 24 h after adjusting for confounding factors. CONCLUSIONS:
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Authors | Raquel Rodríguez-González, Tomás Sobrino, Manuel Rodríguez-Yáñez, Mónica Millán, David Brea, Elena Miranda, Octavio Moldes, Juan Pérez, David A Lomas, Rogelio Leira, Antoni Dávalos, José Castillo |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 9
Pg. 58
(May 11 2011)
ISSN: 1479-5876 [Electronic] England |
PMID | 21569344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Neuropeptides
- Serpins
- neuroserpin
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Topics |
- Aged
- Biomarkers
(blood)
- Brain
(pathology)
- Brain Ischemia
(blood, complications)
- Female
- Humans
- Male
- Neuropeptides
(blood)
- Odds Ratio
- Serpins
(blood)
- Stroke
(blood, complications)
- Time Factors
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