Abstract |
Our previous studies have demonstrated that anthocyanin extract from black rice (AEBR) inhibits atherosclerosis. Whether dietary AEBR supplementation can affect platelet function, an important factor in the pathogenesis of cardiovascular diseases, remains unclear. The aim of the present study is to explore the effects and mechanisms of dietary AEBR supplementation on platelet function and lipid profile in dyslipidemic rats. We demonstrated herein that thromboxane A(2), the thrombogenic ratio of thromboxane A₂ and prostacyclin, serum calmodulin, and soluble P-selectin were significantly decreased in rats fed a high fat diet supplemented with AEBR. AEBR supplementation also remarkably lowered serum triglyceride and raised hepatic CPT-1 mRNA expression. These findings suggest that dietary intake of AEBR reduces platelet hyperactivity, hypertriglyceridemia, and body weight gain, and facilitates in the maintenance of optimal platelet function in dyslipidemic rats induced by high fat diets.
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Authors | Yan Yang, Marc C Andrews, Yan Hu, Dongliang Wang, Yu Qin, Yanna Zhu, Heyu Ni, Wenhua Ling |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 59
Issue 12
Pg. 6759-64
(Jun 22 2011)
ISSN: 1520-5118 [Electronic] United States |
PMID | 21568342
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthocyanins
- Dietary Fats
- Plant Extracts
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Topics |
- Animals
- Anthocyanins
(administration & dosage)
- Blood Platelets
(drug effects)
- Dietary Fats
(adverse effects)
- Disease Models, Animal
- Down-Regulation
(drug effects)
- Dyslipidemias
(drug therapy, metabolism, physiopathology)
- Humans
- Hypertriglyceridemia
(drug therapy, metabolism, physiopathology)
- Male
- Oryza
(chemistry)
- Plant Extracts
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
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