Abstract | INTRODUCTION: AIM: METHODS: Fifty consecutive patients of biopsy proven chronic atrophic gastritis were included in this study. All patients underwent haematological and biochemical tests including serum LDH, vitamin B12 and fasting serum gastrin levels. PCA and IFA antibodies were tested in all patients. Multiple gastric biopsies from body and antrum of the stomach were taken and evaluated for presence of intestinal metaplasia, endocrine cell hyperplasia, carcinoid and H. pylori infection. Patients were grouped as group A (IFA positive) and group B (IFA negative). The mean laboratory values and histological parameters were compared between the two groups using appropriate statistical methods. RESULTS: Eighteen patients were in group A (mean age 55.5 +/- 13 years, male: female = 16:2) and thirty-two in group B (mean age 49.7 +/- 13 years, male: female = 25:7). There was no statistically significant difference between median values of haemoglobin, MCV, LDH, Vitamin B12 and serum gastrin in both the groups. None of the histological parameters showed any significant difference. CONCLUSION: There was no statistically significant difference in haematological, biochemical and histological parameters in IFA positive and negative gastritis. These may be the spectrum of the same disease, where H. pylori may be responsible for initiating the process.
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Authors | D N Amarapurkar, A D Amarapurkar |
Journal | Tropical gastroenterology : official journal of the Digestive Diseases Foundation
(Trop Gastroenterol)
2010 Oct-Dec
Vol. 31
Issue 4
Pg. 266-70
ISSN: 0250-636X [Print] India |
PMID | 21568141
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Intrinsic Factor
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Topics |
- Adult
- Aged
- Anemia, Pernicious
(classification, immunology, pathology)
- Autoantibodies
(immunology)
- Biopsy
- Diagnosis, Differential
- Endoscopy, Digestive System
- Female
- Gastritis, Atrophic
(classification, immunology, pathology)
- Helicobacter Infections
(immunology, pathology)
- Helicobacter pylori
- Humans
- Intrinsic Factor
(immunology)
- Male
- Middle Aged
- Parietal Cells, Gastric
(immunology)
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