Effects of lüfukang capsules on coronary artery ligation-induced arrhythmia in dogs.

Abstract

OBJECTIVE:

To observe the effects of Lüfukang Capsules on arrhythmia induced by ligation of coronary artery in dogs.

METHODS:

Thirty dogs were randomly divided into 5 groups, the model group administrated with equal volume of distilled water, the positive control group administrated with Wenxin Granules, and the small, medium and large dosage LFKC groups, 6 dogs in each group. Thirty minutes after medication, electrocardiogram was conducted and the time of arrhythmia occurrence, times of ventricular premature beat (VP), and incidence rates of ventricular tachycardia (VT) and ventricular fibrillation (VF) were recorded in the model dogs with arrhythmia induced by ligation of coronary artery.

RESULTS:

Compared with the model group, the occurrence time of arrhythmia induced by the coronary artery ligation in the medium and large LFKC groups was significantly delayed (20.45 +/- 9.10 and 19.92 +/- 3.78, respectively, both P < 0.05). The frequency of VP in the medium and large LFKC groups was also significantly decreased (8.17 +/- 6.62 and 3.83 +/- 2.79, respectively, both P < 0.01).

CONCLUSION:

LFKC has anti-arrhythmic effects for the experimental arrhythmia induced by the ligation of coronary artery in dogs.

• Authors: Li-Hua Han, Zhen-Tao Wang, Hong Wu, Hui-Chao Zhang, Shu-Yin Chen, Zi-Jiang Long, Hong-Chao Shen, Rui-Ru Li, Sheng-Wang Liang
• Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan (J Tradit Chin Med) Vol. 31 Issue 1 Pg. 7-9 (Mar 2011) ISSN: 0255-2922 [Print] China
• PMID: 21563498 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Arrhythmia Agents
• Drugs, Chinese Herbal

Topics

• Animals
• Anti-Arrhythmia Agents (administration & dosage)
• Arrhythmias, Cardiac (drug therapy, etiology, surgery)
• Coronary Vessels (drug effects, surgery)
• Disease Models, Animal
• Dogs
• Drugs, Chinese Herbal (administration & dosage)
• Female
• Humans
• Ligation (adverse effects)
• Male