[Diagnostic value of alginate test in gastroesophageal reflux disease].

Abstract

AIM OF STUDY:

To evaluate the diagnostic accuracy of single dose of gaviscon (the alginates test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms.

MATERIAL AND METHODS:

123 patients (male 46, female 77, age 43.6 +/- 15.5 years) with symptoms suggestive of GERD were investigated. Symptom response to the alginates test compared in GERD positive and GERD negative patients according traditional diagnostic criteria of GERD (upper endoscopy, 24-hr pH-monitoring, esophageal manometry, response to treatment with PPIs).

RESULTS:

Of 91 (78.9%) patients with positive alginates test, 87 were classified as GERD positive and 4 as GERD negative. Of 32 (26%) patients with negative alginates test, 29 were GERD negative and 3 GERD positive. The results providing a sensitivity of alginates test of 96.7% and a specificity of 87.7%.

CONCLUSIONS:

The alginates test is sensitive and specific for diagnosing GERD in patients with typical GERD symptoms.

• Authors: D S Bordin, A A Masharova, V N Droxzdov, L D Firsova, T S Kozhurina
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 12 Pg. 102-7 ( 2010) ISSN: 1682-8658 [Print] Russia (Federation)
• PMID: 21560632 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Alginates
• Antacids
• Biocompatible Materials
• Drug Combinations
• Hexuronic Acids
• Silicic Acid
• Aluminum Hydroxide
• alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
• Glucuronic Acid
• Sodium Bicarbonate

Topics

• Adult
• Alginates (administration & dosage)
• Aluminum Hydroxide (administration & dosage)
• Antacids (administration & dosage)
• Biocompatible Materials (administration & dosage)
• Drug Combinations
• Endoscopy, Digestive System (methods)
• Female
• Gastroesophageal Reflux (diagnosis, pathology, physiopathology)
• Glucuronic Acid (administration & dosage)
• Hexuronic Acids (administration & dosage)
• Humans
• Hydrogen-Ion Concentration
• Male
• Middle Aged
• Monitoring, Physiologic (methods)
• Silicic Acid (administration & dosage)
• Sodium Bicarbonate (administration & dosage)