Abstract | OBJECTIVE: to evaluate the five-year prospective study the possibility of using the drug UDCA (Ursosan) for the therapeutic management of patients with BE older. MATERIALS AND METHODS: A prospective open randomized, parallel-group 62 patients of BE with a length of metaplasia less than 3 cm in average age 72.8 +/- 2.8 years. Method of "sealed envelopes" were divided into two equal groups. Patients first--received omeprazole at a daily dose of 40 mg, the second--to combine the same dose of omeprazole drug-Ursosan a daily dose of 10 mg/kg. At baseline and after 4.8+1.2 years assessed the frequency of esophageal, extraesophageal and dyspeptic complaints, endoscopic and morphological pattern of esophageal-gastric junction and lower third of the esophagus. Confirm or exclude the diagnosis of BE during follow-up study was performed after a two-fold endoscopy upper GIT using subdivision techniques for sampling biopsy material and subsequent analysis of biopsy samples pathomorphology of various medical institutions. RESULTS: The combination therapy with omeprazole and drug UDCA contributed to the positive dynamics is the lack of intestinal metaplasia in 32.3% of patients with Barrett's esophagus, whereas monotherapy with omeprazole in a daily dose of 40 mg possible to achieve a similar result in 6.5% of patients (p = 0,01). The frequency of diagnosis of erosive esophagitis decreased after 5 years of therapy with 80.6% to 51.6% (p = 0.016) in the omeprazole group and 86.7% to 16.7% (p < 0.001) in the group receiving omeprazole and the preparation of UDCA. CONCLUSION: This study suggests the possibility of combined therapy with omeprazole and the preparation of UDCA (Ursosan) as a promising means for hemopreventciya Barrett's esophagus in the elderly.
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Authors | E V Onuchina, V V Tsukanov, M F Osipenko |
Journal | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology
(Eksp Klin Gastroenterol)
Issue 12
Pg. 96-101
( 2010)
ISSN: 1682-8658 [Print] Russia (Federation) |
PMID | 21560631
(Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Ulcer Agents
- Cholagogues and Choleretics
- Ursodeoxycholic Acid
- Omeprazole
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Topics |
- Age Factors
- Aged
- Anti-Ulcer Agents
(administration & dosage)
- Barrett Esophagus
(diagnosis, drug therapy, physiopathology)
- Cholagogues and Choleretics
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Male
- Omeprazole
(administration & dosage)
- Prospective Studies
- Ursodeoxycholic Acid
(administration & dosage, analogs & derivatives)
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