Surgical outcome in relation to duct size at the porta hepatis and the use of cholagogues in patients with biliary atresia.

Abstract

BACKGROUND:

Small ductules communicating with the bile ducts have been described at the porta hepatis in extrahepatic biliary atresia (EHBA) and these form the basis for hepatic portoenterostomy. The use of cholagogues like dehydrocholic acid (DHC) and ursodeoxycholic acid (UDCA) to enhance bile flow postoperatively has been reported.

AIMS:

This communication describes our experience with the use of cholagogues following surgery in EHBA and attempts to correlate the outcomes with the diameter of the ductules.

MATERIAL AND METHODS:

Fifty five EHBA patients treated by the Kasai procedure form the basis of this study; 35 patients treated during 1979-1986 and administered DHC (3-5 mg/kg) postoperatively and 20 patients treated during 1999-2002 and administered UDCA (15 mg/kg) postoperatively. The diameter of ductules was measured using an optical micrometer on 5 microm serial sections; the ducts were classified as type I (no demonstrable ducts, n = 14), type II (< 50 microm, n=22) and type III (> 50 microm, n = 19). The clinical outcome was categorized as 1 (jaundice free survival at 5 years follow-up, n = 7), 2 (initial good response but deteriorated after one year, n = 27) and 3 (expired within one year following surgery, n = 21). The response to surgery was monitored using biochemical liver function tests (LFT), hepatobiliary scintigraphy (HIDA scan) and occurrence of cholangitis.

RESULTS:

Age did not affect the size of ducts in both DHC and UDCA groups but patients in the DHC group were older than those treated with UDCA (mean age DHC: 105.22 +/- 33.53 days, UDCA: 74.68 +/- 23.73 days; p = 0.009). There was no statistically significant difference between duct size and postoperative LFT in both groups (DHC p = 0.1, UDCA p = 0.5). Bile excretion on HIDA scan was significantly better with larger ducts (DHC p = 0.003, UDCA p = 0.025); overall UDCA showed significantly better bile excretion (p = 0.003) but this was not reflected in the surgical outcome. There was no significant difference in the surgical outcome of those treated with DHC or UDCA but a significantly higher incidence of cholangitis was seen with smaller ducts in the UDCA group (p = 0.02).

CONCLUSIONS:

There was no correlation between duct diameter and postoperative LFT but type III ducts were associated with better bile flow on HIDA scan. Cholangitis was seen more often with type I and II ducts in both DHC and UDCA groups. UDCA administration seemed to be beneficial in patients with type III ducts in increasing bile flow and reducing cholangitis.

• Authors: M K Mohanty, S Datta Gupta, V Bhatnagar
• Journal: Tropical gastroenterology : official journal of the Digestive Diseases Foundation (Trop Gastroenterol) 2010 Jul-Sep Vol. 31 Issue 3 Pg. 184-9 ISSN: 0250-636X [Print] India
• PMID: 21560523 (Publication Type: Journal Article)

Chemical References

• Ursodeoxycholic Acid
• Dehydrocholic Acid

Topics

• Bile (drug effects)
• Bile Ducts, Extrahepatic (pathology, surgery)
• Bile Ducts, Intrahepatic (pathology, surgery)
• Biliary Atresia (pathology, surgery)
• Combined Modality Therapy
• Dehydrocholic Acid (therapeutic use)
• Female
• Humans
• Infant
• Liver Function Tests
• Male
• Organ Size
• Portoenterostomy, Hepatic
• Treatment Outcome
• Ursodeoxycholic Acid (therapeutic use)