The clinical significance of platelet membrane glycoproteins.

Abstract

To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge of how these receptors function. Elucidation of the role of platelet glycoproteins in normal hemostasis has also provided insight into possible strategies for modulating receptor function in thrombotic disorders and for identifying activated platelets as markers of thrombus formation.

• Authors: R P McEver
• Journal: Hematology/oncology clinics of North America (Hematol Oncol Clin North Am) Vol. 4 Issue 1 Pg. 87-105 (Feb 1990) ISSN: 0889-8588 [Print] United States
• PMID: 2155906 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal
• Fibrinolytic Agents
• Platelet Aggregation Inhibitors
• Platelet Membrane Glycoproteins
• Receptors, Cell Surface

Topics

• Antibodies, Monoclonal
• Blood Platelet Disorders (metabolism)
• Blood Platelets (drug effects)
• Fibrinolytic Agents (pharmacology)
• Humans
• Platelet Activation (physiology)
• Platelet Aggregation Inhibitors (pharmacology)
• Platelet Membrane Glycoproteins (deficiency, immunology, physiology)
• Receptors, Cell Surface (deficiency, physiology)