Abstract | OBJECTIVE: METHODS: Fifty-four patients undergoing laparoscopic cholecystectomy were randomised into two groups: group C and group K. Group K was given ketamine before skin incision. An equal volume of normal saline was given to the patients in group C. Pain was assessed using visual analog scale (VAS) at 10 min after tracheal extubation. The ED50 and ED95 were determined by modified up-and-down method and the incidences of adverse effects were recorded. RESULTS: The incidences of adverse effects were similar in the two groups and the VAS score was significantly lower in group K than in group C. The ED50 and ED95 of ketamine for prevention of postoperative hyperalgesia were 0.24 mg/kg (95%CI, 0.20~0.30 mg/kg) and 0.33 mg/kg (95%CI, 0.28~0.62 mg/kg) respectively. CONCLUSIONS:
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Authors | Li-Hua Hang, Dong-Hua Shao, Yue-Ping Gu |
Journal | Swiss medical weekly
(Swiss Med Wkly)
Vol. 141
Pg. w13195
( 2011)
ISSN: 1424-3997 [Electronic] Switzerland |
PMID | 21557114
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Anesthetics, Intravenous
- Piperidines
- Ketamine
- Remifentanil
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Topics |
- Analgesics
(administration & dosage)
- Anesthetics, Intravenous
(adverse effects)
- Cholecystectomy, Laparoscopic
- Dose-Response Relationship, Drug
- Female
- Humans
- Hyperalgesia
(chemically induced, prevention & control)
- Ketamine
(administration & dosage)
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(chemically induced, prevention & control)
- Piperidines
(adverse effects)
- Remifentanil
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