Abstract |
We describe the light- and electron microscopic, immunohistochemical, cell culture characteristics and cytogenetic findings of a case of dermatofibrosarcoma protuberans (DFSP). Cytogenetically, the lesion exhibited trisomy 8 and a supernumerary ring chromosome as the only clonal abnormalities found in about 35% of the cells analyzed. FISH-analysis of metaphase chromosomes revealed that the ring chromosome contained chromosome 17 sequences. Hybridization with a chromosome 17 centromere specific probe gave three signals in about 19% of the interphase nuclei suggesting that the ring also had a centromere derived from chromosome 17. These observations add to the evidence that supernumerary ring chromosomes, preferentially derived from chromosome 17, and trisomy 8 are non-random abnormalities in DFSP. Our findings also demonstrate the usefulness of FISH for identifying the origin of marker ring chromosomes.
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Authors | G Stenman, H Andersson, J Meiskindblom, E Roijer, L Kindblom |
Journal | International journal of oncology
(Int J Oncol)
Vol. 6
Issue 1
Pg. 81-6
(Jan 1995)
ISSN: 1019-6439 [Print] Greece |
PMID | 21556505
(Publication Type: Journal Article)
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