Abnormal high-density lipoproteins in overweight adolescents with atherogenic dyslipidemia.

Abstract

OBJECTIVE:

This study aimed to evaluate high-density lipoprotein functionality and the cardiovascular risk factor profile in the overweight pediatric population. We hypothesized that overweight adolescents with low high-density lipoprotein cholesterol and elevated triglyceride plasma levels have metabolic abnormalities and dysfunctional high-density lipoprotein particles, similar to those reported in adults.

PATIENTS AND METHODS:

Overweight adolescents with (group 1 [n = 21]) and without (group 2 [n = 36]) atherogenic dyslipidemia (high-density lipoprotein cholesterol: ≤ 40 mg/dL and triglycerides: ≥ 150 mg/dL) and normal-weight normolipidemic subjects, as a reference (group 3 [n = 36]), were included. The cardiovascular risk factor profile (lipids, lipoproteins, high-sensitivity C-reactive protein, and insulin), high-density lipoprotein subclass distribution, composition, and cholesterol efflux capacity were studied.

RESULTS:

Group 1 adolescents showed abnormalities in high-density lipoprotein subclass distribution and high-density lipoprotein chemical composition, as well as a significantly lower capacity to promote cholesterol efflux (14.8 ± 2.8, 16.5 ± 3.8, 20.4 ± 3.5, for groups 1, 2 and 3, respectively). High-density lipoprotein(2a) (R(2) = 0.212, β = 0.472, P < .0001) and the Tanner score (R(2) = 0.054, β = -0.253, P = .02) were the independent predictors of cholesterol efflux. Group 1 also showed a higher degree of cardiovascular abnormalities (an adverse lipoprotein profile, greater insulin resistance and systemic inflammation; and lower low-density lipoprotein size) than group 2, even after BMI and Tanner score adjustment.

CONCLUSIONS:

This study suggests that atherogenic dyslipidemia identifies overweight adolescents with quantitative, qualitative, and functional high-density lipoprotein abnormalities. Atherogenic dyslipidemia seems to be a marker of an increased risk for developing cardiovascular disease and indicates that those adolescents should be a target of aggressive prevention programs and lipid management guidelines.

• Authors: Aida Medina-Urrutia, Juan G Juarez-Rojas, Guillermo Cardoso-Saldaña, Esteban Jorge-Galarza, Rosalinda Posadas-Sánchez, Rocio Martínez-Alvarado, Nacú Caracas-Portilla, Enrique Mendoza Pérez, Carlos Posadas-Romero
• Journal: Pediatrics (Pediatrics) Vol. 127 Issue 6 Pg. e1521-7 (Jun 2011) ISSN: 1098-4275 [Electronic] United States
• PMID: 21555497 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Lipoproteins, HDL

Topics

• Adolescent
• Atherosclerosis (blood, complications, epidemiology)
• Body Weight
• Cross-Sectional Studies
• Dyslipidemias (blood, complications, epidemiology)
• Female
• Follow-Up Studies
• Humans
• Incidence
• Lipoproteins, HDL
• Male
• Mexico (epidemiology)
• Overweight (blood, complications, epidemiology)
• Risk Factors