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Are polyglutamine diseases expanding?

Abstract
It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.
AuthorsHarry T Orr
JournalNeuron (Neuron) Vol. 70 Issue 3 Pg. 377-8 (May 12 2011) ISSN: 1097-4199 [Electronic] United States
PMID21555065 (Publication Type: Comment, Journal Article)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.

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