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4-Azetidinyl-1-heteroatom linked cyclohexane antagonists of CCR2: patent evaluation.

Abstract
This application discloses a series of di- and tri-substituted cyclohexanes as CCR2 receptor antagonists which are stated to be useful in treating inflammation and autoimmune diseases, such as type 2 diabetes and asthma. Although receptor binding of the compounds to CCR2 is demonstrated, there are no data to support the idea that these molecules are functional antagonists.
AuthorsRichard Horuk, William Guilford
JournalExpert opinion on therapeutic patents (Expert Opin Ther Pat) Vol. 21 Issue 8 Pg. 1275-80 (Aug 2011) ISSN: 1744-7674 [Electronic] England
PMID21554155 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents
  • Cyclohexanes
  • Immunologic Factors
  • Receptors, CCR2
Topics
  • Animals
  • Anti-Inflammatory Agents (chemistry, pharmacology)
  • Autoimmunity (drug effects)
  • Cyclohexanes (chemistry, pharmacology)
  • Humans
  • Immunologic Factors (chemistry, pharmacology)
  • Patents as Topic
  • Receptors, CCR2 (antagonists & inhibitors)
  • Structure-Activity Relationship

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