Abstract | AIM: METHODS: Sixty patients, who first developed CAPD peritonitis attacks from February 2008 to April 2010 were included in this study. Patients were divided into two groups, those taking an additional NAC treatment ( n = 30) and a control group ( n = 30). Low- and high-frequency hearing function tests were performed on the two groups before treatment (baseline), at the end of the first (early follow-up) and the fourth week after the treatment (late follow-up). Total doses of vancomycin and amikacin were recorded. RESULTS: There was no statistically significant difference between the groups in terms of hearing functions at the beginning. However, patients taking NAC had better hearing function test results 4 weeks after the treatment compared with those of the control group (P < 0.05). There were no statistical differences between posttreatment low-frequency hearing function tests conducted at the baseline and the first and the fourth weeks in patients taking NAC. The first and the fourth week's low-frequency hearing functions worsened when compared with the baseline low-frequency results in the control group (P < 0.001). It was found that NAC had a protective effect against ototoxicity on low-frequency (0.25-8 KHz) hearing functions. The first and the fourth week's high-frequency hearing functions improved when compared with baseline high-frequency hearing functions in patients taking NAC (P < 0.05), while they worsened. The first and fourth week's high-frequency tests worsened when compared with the baseline high-frequency tests in the control group (P < 0.001). CONCLUSIONS:
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Authors | Bulent Tokgoz, Cahit Ucar, Ismail Kocyigit, Mehmet Somdas, Aydin Unal, Alperen Vural, Murat Sipahioglu, Oktay Oymak, Cengiz Utas |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 26
Issue 12
Pg. 4073-8
(Dec 2011)
ISSN: 1460-2385 [Electronic] England |
PMID | 21551083
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Free Radical Scavengers
- Vancomycin
- Amikacin
- Acetylcysteine
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Topics |
- Acetylcysteine
(therapeutic use)
- Amikacin
(adverse effects)
- Anti-Bacterial Agents
(adverse effects)
- Ear Diseases
(chemically induced, prevention & control)
- Free Radical Scavengers
(therapeutic use)
- Humans
- Peritoneal Dialysis, Continuous Ambulatory
(adverse effects)
- Peritonitis
(drug therapy, etiology)
- Prospective Studies
- Vancomycin
(adverse effects)
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