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Anakinra: an effective treatment in the Schnitzler syndrome.

Abstract
Schnitzler syndrome is a rare disease characterized by chronic urticarial eruption and a monoclonal gammapathy. The exact pathogenesis is still unclear and treatment remains a challenge. We report the case of a patient with a 2-year history of arthralgia, chronic urticaria rash and fever, not responding to different treatments including anti-histaminics, corticosteroids, colchicine and low dose methotrexate. A diagnostic of Schnitzler syndrome was suggested and treatment with anakinra, an interleukin-1 receptor antagonist, was started, leading to a rapid, complete and sustained remission of symptoms. Anakinra seems to constitute an efficient and safe therapeutic approach for this rare disease.
AuthorsMarie-Anne Vandenhende, Fabrice Bentaberry, Philippe Morlat, Fabrice Bonnet
JournalJoint bone spine (Joint Bone Spine) Vol. 78 Issue 6 Pg. 636-7 (Dec 2011) ISSN: 1778-7254 [Electronic] France
PMID21550281 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.
Chemical References
  • Antirheumatic Agents
  • Interleukin 1 Receptor Antagonist Protein
  • Receptors, Interleukin-1
Topics
  • Antirheumatic Agents (therapeutic use)
  • Humans
  • Interleukin 1 Receptor Antagonist Protein (therapeutic use)
  • Male
  • Middle Aged
  • Receptors, Interleukin-1 (antagonists & inhibitors)
  • Remission Induction
  • Schnitzler Syndrome (drug therapy)
  • Treatment Outcome

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