Abstract |
[(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75°C, 4 mg/mL precursor yielding at 48.0±2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183±14 GBq/μmol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.
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Authors | C Philippe, D Haeusler, M Mitterhauser, J Ungersboeck, H Viernstein, R Dudczak, W Wadsak |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 69
Issue 9
Pg. 1212-7
(Sep 2011)
ISSN: 1872-9800 [Electronic] England |
PMID | 21550258
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
- Aniline Compounds
- Benzothiazoles
- Carbon Radioisotopes
- Radiopharmaceuticals
- Thiazoles
|
Topics |
- Alzheimer Disease
(diagnostic imaging)
- Aniline Compounds
- Automation, Laboratory
(methods)
- Benzothiazoles
(chemical synthesis)
- Carbon Radioisotopes
- Humans
- Isotope Labeling
(methods)
- Plaque, Amyloid
(diagnosis, pathology)
- Radionuclide Imaging
- Radiopharmaceuticals
(chemical synthesis)
- Thiazoles
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