Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.

Abstract

The severity of brain tumor associated seizures often mirror the growth of the underlying tumor, and may be intractable to conventional antiepileptic drugs. We present a patient with intractable seizures in the setting of a low grade glioma who responded dramatically to temozolomide despite minimal radiographic change in tumor size. Temozolomide is an effective treatment for seizure control in patients with brain tumors.

• Authors: Alexander Hu, Zhiqiang Xu, Ryan Y Kim, Angel Nguyen, Jong Woo Lee, Santosh Kesari
• Journal: Epilepsy research (Epilepsy Res) Vol. 95 Issue 3 Pg. 270-2 (Aug 2011) ISSN: 1872-6844 [Electronic] Netherlands
• PMID: 21549564 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Alkylating
• Dacarbazine
• Temozolomide

Topics

• Adult
• Antineoplastic Agents, Alkylating (therapeutic use)
• Astrocytoma (complications)
• Brain Neoplasms (complications, drug therapy)
• Dacarbazine (analogs & derivatives, therapeutic use)
• Electroencephalography
• Female
• Humans
• Seizures (drug therapy, etiology)
• Temozolomide