Abstract |
Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of GRK-4 have been linked to impaired natriuresis and salt-sensitive hypertension. The purpose of this report was to determine the effect of GRK-4 gene polymorphisms on the blood pressure (BP) responses to dietary intervention. Black subjects aged 50-75 years with mild-to-moderate hypertension were randomised to an 8-week dietary intervention (n=40) or standard diet (n=40). BP was measured at baseline and at 8 weeks using 24-h ambulatory BP. All subjects underwent DNA analysis for the R65L and A142V polymorphisms. Data were analysed using generalised linear models. For the whole group, between-diet differences in mean 24-h ambulatory systolic BP was -4.53 mm Hg (95% confidence interval -9.05 to -0.01, P=0.05). In the intervention arm, the combined CC and CT group of the A142V showed a significant reduction in both systolic and diastolic ambulatory BP (-10 mm Hg, P=0.023 and -6.5 mm Hg, P=0.01, respectively), whereas the TT group demonstrated no reduction. Similarly, the combined GG and GT groups of the R65L showed a significant reduction in ambulatory BP (-10.6 mm Hg for systolic, P=0.004 and 5.8 mm Hg for diastolic, P=0.006). There was no response in the TT group. GRK-4 polymorphisms predict BP response to dietary modification in Black subjects with mild-to-moderate hypertension. These data may provide at least one among a range of clinical tools to target selected hypertensives to dietary intervention.
|
Authors | B Rayner, R Ramesar, K Steyn, N Levitt, C Lombard, K Charlton |
Journal | Journal of human hypertension
(J Hum Hypertens)
Vol. 26
Issue 5
Pg. 334-9
(May 2012)
ISSN: 1476-5527 [Electronic] England |
PMID | 21544086
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- G-Protein-Coupled Receptor Kinase 4
- GRK4 protein, human
|
Topics |
- Aged
- Black People
(genetics)
- Blood Pressure
(genetics)
- Blood Pressure Monitoring, Ambulatory
- Female
- G-Protein-Coupled Receptor Kinase 4
(genetics)
- Genetic Predisposition to Disease
- Humans
- Hypertension
(diet therapy, enzymology, ethnology, genetics, physiopathology)
- Linear Models
- Male
- Middle Aged
- Patient Selection
- Phenotype
- Polymorphism, Single Nucleotide
- Risk Assessment
- Risk Factors
- Sequence Analysis, DNA
- South Africa
(epidemiology)
- Time Factors
- Treatment Outcome
|