G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.

Abstract

Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of GRK-4 have been linked to impaired natriuresis and salt-sensitive hypertension. The purpose of this report was to determine the effect of GRK-4 gene polymorphisms on the blood pressure (BP) responses to dietary intervention. Black subjects aged 50-75 years with mild-to-moderate hypertension were randomised to an 8-week dietary intervention (n=40) or standard diet (n=40). BP was measured at baseline and at 8 weeks using 24-h ambulatory BP. All subjects underwent DNA analysis for the R65L and A142V polymorphisms. Data were analysed using generalised linear models. For the whole group, between-diet differences in mean 24-h ambulatory systolic BP was -4.53 mm Hg (95% confidence interval -9.05 to -0.01, P=0.05). In the intervention arm, the combined CC and CT group of the A142V showed a significant reduction in both systolic and diastolic ambulatory BP (-10 mm Hg, P=0.023 and -6.5 mm Hg, P=0.01, respectively), whereas the TT group demonstrated no reduction. Similarly, the combined GG and GT groups of the R65L showed a significant reduction in ambulatory BP (-10.6 mm Hg for systolic, P=0.004 and 5.8 mm Hg for diastolic, P=0.006). There was no response in the TT group. GRK-4 polymorphisms predict BP response to dietary modification in Black subjects with mild-to-moderate hypertension. These data may provide at least one among a range of clinical tools to target selected hypertensives to dietary intervention.

• Authors: B Rayner, R Ramesar, K Steyn, N Levitt, C Lombard, K Charlton
• Journal: Journal of human hypertension (J Hum Hypertens) Vol. 26 Issue 5 Pg. 334-9 (May 2012) ISSN: 1476-5527 [Electronic] England
• PMID: 21544086 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• G-Protein-Coupled Receptor Kinase 4
• GRK4 protein, human

Topics

• Aged
• Black People (genetics)
• Blood Pressure (genetics)
• Blood Pressure Monitoring, Ambulatory
• Female
• G-Protein-Coupled Receptor Kinase 4 (genetics)
• Genetic Predisposition to Disease
• Humans
• Hypertension (diet therapy, enzymology, ethnology, genetics, physiopathology)
• Linear Models
• Male
• Middle Aged
• Patient Selection
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors
• Sequence Analysis, DNA
• South Africa (epidemiology)
• Time Factors
• Treatment Outcome