Lack of association between XPD Lys751Gln and Asp312Asn polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

Abstract

PURPOSE:

The published data on the association between xeroderma pigmentosum group D (XPD) Lys751Gln and Asp312Asn polymorphisms and colorectal cancer remained controversial. The present meta-analysis of literatures was performed to derive a more precise estimation of the relationship.

MATERIALS AND METHODS:

A comprehensive literature search was conducted to identify all case-control studies of Lys751Gln and Asp312Asn polymorphisms on the susceptibility of different tumor site of colorectal cancer (colon, rectum, and colon/rectum cancer). A total of 22 eligible studies were selected for this meta-analysis, including 3,042 cases and 4,627 controls for Lys751Gln and 1,581 cases and 2,846 controls for Asp312Asn.

RESULTS:

Overall, no significantly elevated colorectal cancer risk was found in all genetic models when all studies were pooled into the meta-analysis (for Lys751Gln polymorphism: Lys/Gln vs. Lys/Lys, OR = 1.01, 95% CI = 0.90-1.14; Gln/Gln vs. Lys/Lys, OR = 1.04, 95% CI = 0.85-1.26; dominant model, OR = 1.03, 95% CI = 0.93-1.15; recessive model, OR = 1.04, 95% CI = 0.87-1.25; and for Asp312Asn polymorphism: Asp/Asn vs. Asp/Asp, OR = 1.11, 95% CI = 0.91-1.35; Asn/Asn vs. Asp/Asp, OR = 1.13, 95% CI = 0.87-1.47; dominant model, OR = 1.09, 95% CI = 0.94-1.26; recessive model, OR = 1.11, 95% CI = 0.88-1.41). And for the additive model, individuals carrying the 751Gln or 312Asn allele were not significantly associated with increased risk to colorectal cancer (OR = 1.02, 95% CI = 0.94-1.11, OR = 1.07, 95% CI = 0.95-1.20).

CONCLUSION:

This meta-analysis suggests that XPD Lys751Gln and Asp312Asn polymorphisms may not be associated with colorectal cancer development.

• Authors: Ying Zhang, Dapeng Ding, Xiaoxue Wang, Zhenglan Zhu, Meiyan Huang, Xiaofeng He
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 26 Issue 10 Pg. 1257-64 (Oct 2011) ISSN: 1432-1262 [Electronic] Germany
• PMID: 21541661 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Xeroderma Pigmentosum Group D Protein
• ERCC2 protein, human

Topics

• Amino Acid Substitution (genetics)
• Case-Control Studies
• Colorectal Neoplasms (genetics)
• Databases as Topic
• Gene Frequency (genetics)
• Genetic Association Studies
• Genetic Heterogeneity
• Genetic Predisposition to Disease
• Humans
• Models, Genetic
• Odds Ratio
• Polymorphism, Single Nucleotide (genetics)
• Publication Bias
• Risk Factors
• Xeroderma Pigmentosum Group D Protein (genetics)