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Measurement of O-6-methylguanine-DNA methyltransferase activity using oligonucleotides and restriction enzyme in human brain tumors.

Abstract
We determined the levels of MGMT activity in 46 human brain tumors, using oligonucleotides containing O-6-methylguanine at a PvuII recognition site, and correlated MGMT activity with chemotherapeutic effectiveness in 14 patients with high-grade gliomas who received ACNU chemotherapy. The results characterize MGMT activities among different types and within individual types of human brain tumors. A certain fraction of gliomas exhibited a low value of MGMT activity. Tumors showing a low MGMT activity responded well to ACNU and resulted in prolongation in the time to tumor progression. Thus, the low MGMT activity of gliomas may provide a theoretical basis for application of CENU chemotherapy.
AuthorsT Yanagisawa, K Watanabe, K Mineura, M Kowada
JournalInternational journal of oncology (Int J Oncol) Vol. 9 Issue 4 Pg. 781-6 (Oct 1996) ISSN: 1019-6439 [Print] Greece
PMID21541583 (Publication Type: Journal Article)

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