Abstract |
We determined the levels of MGMT activity in 46 human brain tumors, using oligonucleotides containing O-6-methylguanine at a PvuII recognition site, and correlated MGMT activity with chemotherapeutic effectiveness in 14 patients with high-grade gliomas who received ACNU chemotherapy. The results characterize MGMT activities among different types and within individual types of human brain tumors. A certain fraction of gliomas exhibited a low value of MGMT activity. Tumors showing a low MGMT activity responded well to ACNU and resulted in prolongation in the time to tumor progression. Thus, the low MGMT activity of gliomas may provide a theoretical basis for application of CENU chemotherapy.
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Authors | T Yanagisawa, K Watanabe, K Mineura, M Kowada |
Journal | International journal of oncology
(Int J Oncol)
Vol. 9
Issue 4
Pg. 781-6
(Oct 1996)
ISSN: 1019-6439 [Print] Greece |
PMID | 21541583
(Publication Type: Journal Article)
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