Diagnostic value of I-131 NP-59 SPECT/CT scintigraphy in patients with subclinical or atypical features of primary aldosteronism.

Abstract

Accumulating evidence has shown the adverse effect of long-term hyperaldosteronism on cardiovascular morbidity that is independent of blood pressure. However, the diagnosis of primary aldosteronism (PA) remains a challenge for patients who present with subtle or atypical features or have chronic kidney disease (CKD). SPECT/CT has proven valuable in the diagnosis of a number of conditions. The aim of this study was to determine the usefulness of I-131 NP-59 SPECT/CT in patients with atypical presentations of PA and in those with CKD. The records of 15 patients with PA were retrospectively analyzed. NP-59 SPECT/CT was able to identify adrenal lesion(s) in CKD patients with suspected PA. Patients using NP-59 SPECT/CT imaging, compared with those not performing this procedure, significantly featured nearly normal serum potassium levels, normal aldosterone-renin ratio, and smaller adrenal size on CT and pathological examination and tended to feature stage 1 hypertension and non-suppressed plasma renin activity. These findings show that noninvasive NP-59 SPECT/CT is a useful tool for diagnosis in patients with subclinical or atypical features of PA and those with CKD.

• Authors: Yi-Chun Chen, Yu-Chieh Su, Chang-Kuo Wei, Jainn-Shiun Chiu, Chih-En Tseng, Shao-Jer Chen, Yuh-Feng Wang
• Journal: Journal of biomedicine & biotechnology (J Biomed Biotechnol) Vol. 2011 Pg. 209787 ( 2011) ISSN: 1110-7251 [Electronic] United States
• PMID: 21541242 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes
• Adosterol

Topics

• Adosterol
• Adult
• Aged
• Case-Control Studies
• Demography
• Female
• Humans
• Hyperaldosteronism (diagnostic imaging, pathology)
• Iodine Radioisotopes
• Male
• Mass Screening
• Middle Aged
• Radionuclide Imaging
• Reproducibility of Results
• Tomography, Emission-Computed, Single-Photon
• Tomography, X-Ray Computed
• Treatment Outcome