Abstract | BACKGROUND/OBJECTIVES: SUBJECTS/METHODS: The study was a randomised, cross-over, double-blind, placebo-controlled acute meal study. Twenty healthy volunteers (11 females and 9 males) were recruited, and all subjects completed the study. Fasted volunteers consumed a 20% blackcurrant juice drink (250 ml) or a control drink following a low- flavonoid diet for the previous 72 h. Vascular reactivity was assessed at baseline and 120 min after juice consumption by laser Doppler imaging (LDI). Plasma and urine samples were collected periodically over an 8-h period for analysis, with a final urine sample collected at 24 h. The cross-over was performed after a 4-week washout. RESULTS: CONCLUSIONS: The juice consumption did not have a significant effect on vascular reactivity. Anthocyanins were present at low concentrations in the urine, and microbial metabolites of flavonoids were detected in plasma after juice consumption.
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Authors | Y Jin, D Alimbetov, T George, M H Gordon, J A Lovegrove |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 65
Issue 7
Pg. 849-56
(Jul 2011)
ISSN: 1476-5640 [Electronic] England |
PMID | 21540876
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthocyanins
- Antioxidants
- Biomarkers
- Phenols
- Vascular Cell Adhesion Molecule-1
- Intercellular Adhesion Molecule-1
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Topics |
- Adult
- Anthocyanins
(analysis, metabolism, therapeutic use, urine)
- Antioxidants
(analysis)
- Beverages
(analysis)
- Biological Availability
- Biomarkers
(blood)
- Blood Vessels
(drug effects, physiology)
- Cardiovascular Diseases
(epidemiology, prevention & control)
- Cross-Over Studies
- Double-Blind Method
- Female
- Fruit
(chemistry)
- Humans
- Intercellular Adhesion Molecule-1
(blood)
- Male
- Middle Aged
- Nutritive Value
- Phenols
(blood, urine)
- Ribes
(chemistry)
- Risk Factors
- United Kingdom
(epidemiology)
- Vascular Cell Adhesion Molecule-1
(blood)
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