Novel polymeric/lipidic hybrid systems (PLHs) for effective Cidofovir delivery: preparation, characterization and comparative in vitro study with polymeric particles and liposomes.

Abstract

Cidofovir is an antiviral drug active as antitumoral agent a high doses against the Primary Effusion Lymphoma, a herpesvirus HHV8-associated B-cell lymphoma. A novel polymeric/lipidic hybrid system, consisting in a specific combination of biocompatible materials, capable to build a crossbred between polymeric particles and liposomes were prepared and used to stabilize and deliver the drug, unsuccessfully formulated into several types of carriers. This innovative cidofovir-delivering system has structurally been characterized in comparison to multilamellar liposomes and polymeric particles, and then tested for antitumoral efficacy against tumor cells (BCBL-1 cell line). The results demonstrated the improving of drug stability and encapsulation efficiency and suggested that polymeric/lipidic hybrid system could be promising to improve the antitumoral effect of cidofovir even at lower doses.

• Authors: Daniela Belletti, Giovanni Riva, Giovanni Tosi, Flavio Forni, Patrizia Barozzi, Mario Luppi, Maria Angela Vandelli, Barbara Ruozi
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 413 Issue 1-2 Pg. 220-8 (Jul 15 2011) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 21536117 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Antiviral Agents
• Drug Carriers
• Excipients
• Lipids
• Liposomes
• Organophosphonates
• Polyesters
• Polymers
• poly(lactide)
• Cytosine
• Cidofovir

Topics

• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Antiviral Agents (administration & dosage, chemistry)
• Cell Line, Tumor
• Cidofovir
• Cytosine (administration & dosage, analogs & derivatives, chemistry, pharmacology)
• Desiccation
• Diffusion
• Drug Carriers
• Drug Compounding
• Drug Delivery Systems (methods)
• Drug Stability
• Excipients (chemistry)
• Herpesvirus 8, Human (drug effects)
• Humans
• Lipids (analysis, chemistry)
• Liposomes (analysis, chemistry)
• Organophosphonates (administration & dosage, chemistry, pharmacology)
• Particle Size
• Polyesters (chemistry)
• Polymers (chemistry)