Abstract | OBJECTIVES:
Diffuse brain injury ( DBI) has been shown to increase the proliferation of granule cell precursors in the adult dentate gyrus (DG). However, the mechanism by which DBI-induced cell proliferation in the DG may enhance seizure susceptibility remains largely unknown. MATERIALS AND METHODS: RESULTS: It has been found that 2R,4R-APDC significantly blocked DBI-induced increase in the number of BrdU-positive cells in the DG, especially in hilus. In addition, double-label immunofluorescence staining showed that treatment with APDC did not affect the differentiation of newborn cells into neurons or astrocytes. Taken together, our findings indicate that the activation of mGluR system may inhibit the DBI-induced cell proliferation in the DG, but not the differentiation of newborn cells. DISCUSSION: It is suggested that 2R,4R-APDC has potential neuroprotection via inhibiting the aberrant neurogenesis induced by DBI, which is an important pathological basis of seizure or other abnormalities following DBI.
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Authors | Ya-Bo Feng, Hong Yao, Xiao Man, Ling-Yi Chi, Zhao-Fu Chi |
Journal | Neurological research
(Neurol Res)
Vol. 33
Issue 4
Pg. 381-8
(May 2011)
ISSN: 1743-1328 [Electronic] England |
PMID | 21535937
(Publication Type: Journal Article)
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Chemical References |
- 4-aminopyrrolidine-2,4-dicarboxylic acid
- Excitatory Amino Acid Agonists
- Neuroprotective Agents
- Receptors, Metabotropic Glutamate
- metabotropic glutamate receptor 2
- Proline
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Topics |
- Animals
- Brain Injuries
(drug therapy, mortality, pathology)
- Cell Proliferation
(drug effects)
- Dentate Gyrus
(drug effects, metabolism, pathology)
- Disease Models, Animal
- Excitatory Amino Acid Agonists
(pharmacology, therapeutic use)
- Male
- Nerve Regeneration
(drug effects, physiology)
- Neural Stem Cells
(drug effects, metabolism, pathology)
- Neurogenesis
(drug effects, physiology)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Proline
(analogs & derivatives, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Receptors, Metabotropic Glutamate
(agonists, physiology)
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