Abstract | BACKGROUND: METHODS: We conducted a retrospective analysis in patients diagnosed with noncomplicated scrub typhus by serologic or molecular methods from August 2001 to July 2007. We compared the efficacy of intravenous minocycline with oral doxycycline for treatment of noncomplicated scrub typhus in these patients. RESULTS: Forty seven cases receiving tetracycline antibiotics for the treatment of noncomplicated scrub typhus were included. There was no statistically significant difference for the response rate between the 25 cases receiving intravenous minocycline (96%) and the 22 cases receiving oral doxycycline (91%) (p=0.909). Kaplan-Meier curve with a long-rank test for the time to defervescence showed no statistically significant difference between minocycline therapy (mean 30 hours; range 4-124 hours) and doxycycline therapy (mean 32.4 hours; range 4-144 hours) (p=0.860). After multivariate Cox regression models, the time to defervescence was only affected by Acute Physiology and Chronic Health Evaluation II score (hazard ratio 0.868; p=0.016). Nearly all patients (93.6%) became afebrile within 72 hours after use of tetracycline antibiotics. Prolonged hospitalization (> 7 days) was correlated with the timing to start tetracycline antibiotics after admission. CONCLUSION:
|
Authors | Chen-Chi Tsai, Chorng-Jang Lay, Yu-Huai Ho, Lih-Shinn Wang, Li-Kuang Chen |
Journal | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
(J Microbiol Immunol Infect)
Vol. 44
Issue 1
Pg. 33-8
(Feb 2011)
ISSN: 1995-9133 [Electronic] England |
PMID | 21531350
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2011. Published by Elsevier B.V. |
Chemical References |
- Anti-Bacterial Agents
- Minocycline
- Doxycycline
|
Topics |
- Administration, Intravenous
- Administration, Oral
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Doxycycline
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Minocycline
(administration & dosage)
- Retrospective Studies
- Scrub Typhus
(drug therapy)
- Treatment Outcome
|