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The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.

AbstractBACKGROUND:
Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene-environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults.
OBJECTIVES:
To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma.
METHODS:
A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations.
RESULTS:
The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41-0.92; P = .018) in children and young adults with asthma.
CONCLUSIONS:
Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.
AuthorsJason Cunningham, Kaninika Basu, Roger Tavendale, Colin N A Palmer, Helen Smith, Somnath Mukhopadhyay
JournalAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Ann Allergy Asthma Immunol) Vol. 106 Issue 5 Pg. 381-6 (May 2011) ISSN: 1534-4436 [Electronic] United States
PMID21530869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Adipokines
  • Anti-Asthmatic Agents
  • CHI3L1 protein, human
  • Glycoproteins
  • Lectins
Topics
  • Absenteeism
  • Adipokines
  • Adolescent
  • Adult
  • Anti-Asthmatic Agents (therapeutic use)
  • Asthma (drug therapy, genetics)
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Gene Dosage (genetics)
  • Glycoproteins (genetics)
  • Heterozygote
  • Homozygote
  • Hospitalization (statistics & numerical data)
  • Humans
  • Lectins (genetics)
  • Male
  • Polymorphism, Single Nucleotide (genetics)
  • Scotland
  • Students (statistics & numerical data)
  • Young Adult

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